A series of isoxazole-based histone deacetylase (HDAC) inhibitors structurally related to SAHA were designed and synthesized. The isoxazole moiety was inserted in the vicinity of the Zn2+-binding group in order to check its participation in the coordinating process. New isoxazole-based histone deacetylase inhibitors structurally related to SAHA were designed and synthesized to check the participation of the isoxazole moiety in the Zn 2+coordination.
Design and synthesis of novel isoxazole-based HDAC inhibitors / P. Conti, L. Tamborini, A. Pinto, L. Sola, R. Ettari, C. Mercurio, C. De Micheli. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - 45:9(2010 Sep), pp. 4331-4338. [10.1016/j.ejmech.2010.06.035]
Design and synthesis of novel isoxazole-based HDAC inhibitors
P. Conti
Primo
;L. TamboriniSecondo
;A. Pinto;L. Sola;C. De MicheliUltimo
2010
Abstract
A series of isoxazole-based histone deacetylase (HDAC) inhibitors structurally related to SAHA were designed and synthesized. The isoxazole moiety was inserted in the vicinity of the Zn2+-binding group in order to check its participation in the coordinating process. New isoxazole-based histone deacetylase inhibitors structurally related to SAHA were designed and synthesized to check the participation of the isoxazole moiety in the Zn 2+coordination.
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