The model of cancer stem cells in tumor development states that tumors contain a subset of cells that both self renew and give rise to differentiated progeny. Like normal adult tissue stem cells, cancer stem cells are a minority of the whole tumor and are the only cells that are able to maintain tumor growth indefinitely. In the present review is critically discussed the actually existence of a cancer stem cell subpopulation in melanoma. The self-renewal signaling pathways as well as specific markers like as CD133, ABCB5 and ABCG2 recently identified in putative melanoma cancer stem cells are also discussed.
Cancer Stem cells : lessons from melanoma / C. La Porta. - In: STEM CELL REVIEWS. - ISSN 1550-8943. - 5:1(2009), pp. 61-65. [10.1007/s12015-008-9048-7]
Cancer Stem cells : lessons from melanoma
C. La PortaPrimo
2009
Abstract
The model of cancer stem cells in tumor development states that tumors contain a subset of cells that both self renew and give rise to differentiated progeny. Like normal adult tissue stem cells, cancer stem cells are a minority of the whole tumor and are the only cells that are able to maintain tumor growth indefinitely. In the present review is critically discussed the actually existence of a cancer stem cell subpopulation in melanoma. The self-renewal signaling pathways as well as specific markers like as CD133, ABCB5 and ABCG2 recently identified in putative melanoma cancer stem cells are also discussed.
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