Summary. One of the major events that characterize spermiogenenesis is the formation of the acrosome. Acrosome-less spermatozoa are infertile; in human, globozoospermia is a rare but severe disorder in male infertility. The acrosome formation is far more complicated than has been so far proposed. Here we address attention to the ubiquitin-dependent protein/vesicle sorting during acrosomogenesis, with a particular focus to the early endosome compartment and retrograde traffic. The acrosome shares features with lysosome-related organelles (LROs), the biogenesis of which employs a common machinery whose genetic defects can affect all LROs or only an individual LRO. The Wobbler mouse, an animal mutant characterized by motor neuron disorders and male infertility
Relationship between UBPy and the Endosome System in Acrosome Biogenesis / G. Berruti - In: 9th International Congress of Andrology / [a cura di] J.L. Ballescà, R. Oliva Virgili. - Bologna : Medimond, 2009. - ISBN 978-88-7587-530-5. - pp. 11-17 (( Intervento presentato al 9. convegno International Congress of Andrology tenutosi a Barcellona nel 2009.
Relationship between UBPy and the Endosome System in Acrosome Biogenesis
G. BerrutiPrimo
2009
Abstract
Summary. One of the major events that characterize spermiogenenesis is the formation of the acrosome. Acrosome-less spermatozoa are infertile; in human, globozoospermia is a rare but severe disorder in male infertility. The acrosome formation is far more complicated than has been so far proposed. Here we address attention to the ubiquitin-dependent protein/vesicle sorting during acrosomogenesis, with a particular focus to the early endosome compartment and retrograde traffic. The acrosome shares features with lysosome-related organelles (LROs), the biogenesis of which employs a common machinery whose genetic defects can affect all LROs or only an individual LRO. The Wobbler mouse, an animal mutant characterized by motor neuron disorders and male infertilityPubblicazioni consigliate
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