In our case–control study we analyzed two functional IL18 gene promoter polymorphisms (−137 G/C and −607 C/A) and an additional polymorphism at position −656 (G/T) in Alzheimer patients and healthy controls in order to verify the involvement of these genetic variations in the onset of Alzheimer disease. No significant differences were detected for the three IL18 SNPs between AD patients and controls. The haplotypes distribution also did not show any difference within AD subjects and controls
Lack of association between Interleukin-18 gene promoter polymorphisms and onset of Alzheimer's disease / L. Segat, M. Milanese, B. Arosio, C. Vergani, S. Crovella. - In: NEUROBIOLOGY OF AGING. - ISSN 0197-4580. - 31:1(2010 Jan), pp. 162-164.
Lack of association between Interleukin-18 gene promoter polymorphisms and onset of Alzheimer's disease
B. Arosio;C. VerganiPenultimo
;
2010
Abstract
In our case–control study we analyzed two functional IL18 gene promoter polymorphisms (−137 G/C and −607 C/A) and an additional polymorphism at position −656 (G/T) in Alzheimer patients and healthy controls in order to verify the involvement of these genetic variations in the onset of Alzheimer disease. No significant differences were detected for the three IL18 SNPs between AD patients and controls. The haplotypes distribution also did not show any difference within AD subjects and controlsPubblicazioni consigliate
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