An efficient short protocol for the preparation of N-perfluoroacylated glycals of neuraminic acid, by simple short treatment of differently protected N-acetylneuraminic acid with perfluorinated anhydrides in acetonitrile at 135 °C, is reported, together with a rationalitazion of the reaction that allows to preview the alternative formation of N-perfluoroacylated 1,7-lactones under the same reaction conditions.
Reaction of N-acetylneuraminic acid derivatives with perfluorinated anhydrides : a short access to N-perfluoracylated glycals with antiviral properties / P. Rota, P. Allevi, R. Mattina, M. Anastasia. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0520. - 8:16(2010 Jun 17), pp. 3771-3776. [10.1039/C004938G]
Reaction of N-acetylneuraminic acid derivatives with perfluorinated anhydrides : a short access to N-perfluoracylated glycals with antiviral properties
P. RotaPrimo
;P. AlleviSecondo
;R. MattinaPenultimo
;M. AnastasiaUltimo
2010
Abstract
An efficient short protocol for the preparation of N-perfluoroacylated glycals of neuraminic acid, by simple short treatment of differently protected N-acetylneuraminic acid with perfluorinated anhydrides in acetonitrile at 135 °C, is reported, together with a rationalitazion of the reaction that allows to preview the alternative formation of N-perfluoroacylated 1,7-lactones under the same reaction conditions.
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