The present invention refers to an oral dosage form intended for the time-controlled release of drugs comprising a container for one or more active ingredients optionally in admixture with pharmaceutically acceptable excipients, said container consisting of at least two parts or elements that can be joined together so as to seal the contents, at least one of said elements being composed of one or more hydrophilic polymers that undergo a decrease in the glassy-rubbery transition temperature when in contact with aqueous fluids, except for polymers with pH dependent solubility soluble only at pH values above 5, optionally in admixture with pharmaceutically acceptable excipients, the wall of the elements of the container being of such thickness as to delay the release of the contained drug with respect to the time of administration.

Pharmaceutical Dosage Forms for Time-Specific Drug Delivery / A. Gazzaniga, M. Cerea, A. Cozzi, A. Foppoli, M.E. Sangalli, L. Zema.

Pharmaceutical Dosage Forms for Time-Specific Drug Delivery

A. Gazzaniga
Primo
;
M. Cerea
Secondo
;
A. Cozzi;A. Foppoli;M.E. Sangalli
Penultimo
;
L. Zema
Ultimo
2010

Abstract

The present invention refers to an oral dosage form intended for the time-controlled release of drugs comprising a container for one or more active ingredients optionally in admixture with pharmaceutically acceptable excipients, said container consisting of at least two parts or elements that can be joined together so as to seal the contents, at least one of said elements being composed of one or more hydrophilic polymers that undergo a decrease in the glassy-rubbery transition temperature when in contact with aqueous fluids, except for polymers with pH dependent solubility soluble only at pH values above 5, optionally in admixture with pharmaceutically acceptable excipients, the wall of the elements of the container being of such thickness as to delay the release of the contained drug with respect to the time of administration.
Università degli studi di Milano
WO2010/009891
PCT/EP2009/005370
28-gen-2010
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
http://sobjprd.questel.fr/sobj/servlet/get_pds/WO201009891A1.pdf?userid=qptui001&type=0&pdfid=17338924&ekey=988&id=1449654969
http://hdl.handle.net/2434/145871
Pharmaceutical Dosage Forms for Time-Specific Drug Delivery / A. Gazzaniga, M. Cerea, A. Cozzi, A. Foppoli, M.E. Sangalli, L. Zema.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/145870
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