The first total enantiosynthesis of the biologically active alkaloid (-)-cytisine is reported, featuring a ruthenium-catalyzed RCM reaction as the key step. The approach relies on readily available cis-piperidine-3,5-dimethanol monoacetate as the chiral building block, and it is suited for achieving the target compound in both enantiomeric forms.

Total Enantioselective Synthesis of (-)-Cytisine / B. Danieli, G. Lesma, D. Passarella, A. Sacchetti, A. Silvani, A. Virdis. - In: ORGANIC LETTERS. - ISSN 1523-7060. - 6:4(2004), pp. 493-496.

Total Enantioselective Synthesis of (-)-Cytisine

B. Danieli
Primo
;
G. Lesma
Secondo
;
D. Passarella;A. Silvani
Penultimo
;
2004

Abstract

The first total enantiosynthesis of the biologically active alkaloid (-)-cytisine is reported, featuring a ruthenium-catalyzed RCM reaction as the key step. The approach relies on readily available cis-piperidine-3,5-dimethanol monoacetate as the chiral building block, and it is suited for achieving the target compound in both enantiomeric forms.
Settore CHIM/06 - Chimica Organica
2004
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/144481
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