The first total enantiosynthesis of the biologically active alkaloid (-)-cytisine is reported, featuring a ruthenium-catalyzed RCM reaction as the key step. The approach relies on readily available cis-piperidine-3,5-dimethanol monoacetate as the chiral building block, and it is suited for achieving the target compound in both enantiomeric forms.
Total Enantioselective Synthesis of (-)-Cytisine / B. Danieli, G. Lesma, D. Passarella, A. Sacchetti, A. Silvani, A. Virdis. - In: ORGANIC LETTERS. - ISSN 1523-7060. - 6:4(2004), pp. 493-496.
Total Enantioselective Synthesis of (-)-Cytisine
B. DanieliPrimo
;G. LesmaSecondo
;D. Passarella;A. SilvaniPenultimo
;
2004
Abstract
The first total enantiosynthesis of the biologically active alkaloid (-)-cytisine is reported, featuring a ruthenium-catalyzed RCM reaction as the key step. The approach relies on readily available cis-piperidine-3,5-dimethanol monoacetate as the chiral building block, and it is suited for achieving the target compound in both enantiomeric forms.File in questo prodotto:
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