here is growing interest in dietary phytochemicals as potential cancer chemopreventive agents. Resveratrol (3,4′,5-trihydroxy-trans-stilbene), a naturally occurring phytoalexin that is present in grapes, red wine, berries and peanuts, has been studied extensively for its ability to interfere with multistage carcinogenesis. Resveratrol is known to have antioxidant, anti-inflammatory and antiproliferative effects on a variety of cancer cells in vitro and in various animal models. However, the effect(s) of resveratrol in vivo on humans are still controversial. This study discusses current knowledge with regard to the effects of resveratrol in relation to its potential as a chemopreventive and/or chemotherapeutic molecule against human gliomas.

The potential of resveratrol against human gliomas / N. Gagliano, G. Aldini, G. Colombo, R. Rossi, R. Colombo, M. Gioia, A. Milzani, I. Dalle-Donne. - In: ANTI-CANCER DRUGS. - ISSN 0959-4973. - 21:2(2010), pp. 140-150.

The potential of resveratrol against human gliomas

N. Gagliano
;
G. Aldini
Secondo
;
G. Colombo;R. Colombo;M. Gioia;A. Milzani
Penultimo
;
I. Dalle-Donne
Ultimo
2010

Abstract

here is growing interest in dietary phytochemicals as potential cancer chemopreventive agents. Resveratrol (3,4′,5-trihydroxy-trans-stilbene), a naturally occurring phytoalexin that is present in grapes, red wine, berries and peanuts, has been studied extensively for its ability to interfere with multistage carcinogenesis. Resveratrol is known to have antioxidant, anti-inflammatory and antiproliferative effects on a variety of cancer cells in vitro and in various animal models. However, the effect(s) of resveratrol in vivo on humans are still controversial. This study discusses current knowledge with regard to the effects of resveratrol in relation to its potential as a chemopreventive and/or chemotherapeutic molecule against human gliomas.
Glioma; Oxidative stress; Resveratrol; Tumour progression
Settore CHIM/08 - Chimica Farmaceutica
Settore BIO/06 - Anatomia Comparata e Citologia
2010
Article (author)
File in questo prodotto:
File Dimensione Formato  
00001813-201002000-00002.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 188.66 kB
Formato Adobe PDF
188.66 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/144028
Citazioni
  • ???jsp.display-item.citation.pmc??? 14
  • Scopus 47
  • ???jsp.display-item.citation.isi??? 45
social impact