Data reported in the literature on neoplastic transformation induced in cultured cells by light charged particles are compared and analyzed as a function of LET and dose protraction. Light charged particles RBE for transformation is maximum between 75 and 120 keV/μm . The majority of the data suggest that RBE values for survival and transformation are of similar magnitude. Dose protraction effects on transformation induction depend on dose, dose rate and on radiation quality.
Cell transformation by light particles : review of available data / D. Bettega. - In: RADIOTHERAPY AND ONCOLOGY. - ISSN 0167-8140. - 73:suppl. 2(2004 Dec), pp. S155-S157. ((Intervento presentato al convegno 9th Workshop on Heavy Charged Particles in Biology and Medicine and 3rd ENLIGHT tenutosi a Lyon nel 2003.
Cell transformation by light particles : review of available data
D. BettegaPrimo
2004
Abstract
Data reported in the literature on neoplastic transformation induced in cultured cells by light charged particles are compared and analyzed as a function of LET and dose protraction. Light charged particles RBE for transformation is maximum between 75 and 120 keV/μm . The majority of the data suggest that RBE values for survival and transformation are of similar magnitude. Dose protraction effects on transformation induction depend on dose, dose rate and on radiation quality.
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