Polyamidoamines (PAAs) represent a family of degradable polymers carrying ter-amine groups in the polymer backbone, which behave as polyelectrolytes in aqueous solutions. Many relevant properties of PAAs, including the ability to interact with components of the biological environments, such as nucleic acids, proteins, and living cells, are strongly dependent on their acid-base properties, hence on their ionization state in different biological districts. In this article, the protonation constants of a series of PAAs have been precisely determined by electrochemical techniques in order to build up a homogeneous library containing both the protonation constants and the average distribution of the charged species, hence the net average charge as a function of pH. Moreover, correlations between chemical and cytotoxicity, have been attempted.
Acid-Base Properties of Poly(amidoamine)s / E. Ranucci, P. Ferruti, E. Lattanzio, A.G. Manfredi, M. Rossi, P.R. Mussini, F. Chiellini, C. Bartoli. - In: JOURNAL OF POLYMER SCIENCE. PART A, POLYMER CHEMISTRY. - ISSN 0887-624X. - 47:24(2009), pp. 6977-6991. [10.1002/pola.23737]
Acid-Base Properties of Poly(amidoamine)s
E. RanucciPrimo
;P. FerrutiSecondo
;E. Lattanzio;A.G. Manfredi;M. Rossi;P.R. Mussini;
2009
Abstract
Polyamidoamines (PAAs) represent a family of degradable polymers carrying ter-amine groups in the polymer backbone, which behave as polyelectrolytes in aqueous solutions. Many relevant properties of PAAs, including the ability to interact with components of the biological environments, such as nucleic acids, proteins, and living cells, are strongly dependent on their acid-base properties, hence on their ionization state in different biological districts. In this article, the protonation constants of a series of PAAs have been precisely determined by electrochemical techniques in order to build up a homogeneous library containing both the protonation constants and the average distribution of the charged species, hence the net average charge as a function of pH. Moreover, correlations between chemical and cytotoxicity, have been attempted.Pubblicazioni consigliate
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