Objective: To assess whether the use of new B-mode imaging technologies, which allow the direct storage of series of single digitalized images in electronic supports (CD-rom) in place of movies continuously recorded on analogical supports (s-VHS videotapes), may compromise the accuracy, precision and repeatability of carotid artery intima media thickness (IMT) measurements. Methods: The agreement between 121 replicated-scans stored as movies on s-VHS videotapes was compared with the agreement obtained with 121 replicated-scans stored as series of single frozen images on CD-rom. Results: The intra-method agreement was highest with movies recorded on s-VHS videotapes, with a bias between log-transformed readings of 0.0017±0.0305, mean absolute difference of 0.0210±0.0222 and repeatability coefficient of 0.061. The digital system provided a slightly lower repeatability with a bias between readings of −0.0040±0.0343, mean absolute difference of 0.0266±0.0219 and repeatability coefficient of 0.069. When the two methods were compared, the log-transformed bias between readings was 0.0169±0.06 with higher values obtained with s-VHS, the repeatability coefficient being 0.124, with almost all points within ±2SD of the mean difference. The mean absolute difference between the two measurements was 0.042±0.046. Conclusions: Compared with movies recorded on videotapes, the direct storage of series of single digitalized images in CD-rom for IMT evaluation associates with a lower agreement (-28%) between replicate scans. This implies the need of sample size larger of about 28% when this technology is used in IMT-progression clinical trials. Funding: European Project, IMPROVE QLG1-CT-2002-00896.

Carotid IMT measurements : a comparison between S-VHS or cd-rom recorded ultrasonic scans / S. Castelnuovo, E. Tremoli, D. Baldassarre, I. Study Group. - In: ATHEROSCLEROSIS SUPPLEMENTS. - ISSN 1567-5688. - 10:2(2009), pp. e1044-e1044. ((Intervento presentato al 15. convegno International Symposium on Atherosclerosis tenutosi a Boston nel 2009 [10.1016/S1567-5688(09)71020-7].

Carotid IMT measurements : a comparison between S-VHS or cd-rom recorded ultrasonic scans

S. Castelnuovo
Primo
;
E. Tremoli
Secondo
;
D. Baldassarre
Penultimo
;
2009

Abstract

Objective: To assess whether the use of new B-mode imaging technologies, which allow the direct storage of series of single digitalized images in electronic supports (CD-rom) in place of movies continuously recorded on analogical supports (s-VHS videotapes), may compromise the accuracy, precision and repeatability of carotid artery intima media thickness (IMT) measurements. Methods: The agreement between 121 replicated-scans stored as movies on s-VHS videotapes was compared with the agreement obtained with 121 replicated-scans stored as series of single frozen images on CD-rom. Results: The intra-method agreement was highest with movies recorded on s-VHS videotapes, with a bias between log-transformed readings of 0.0017±0.0305, mean absolute difference of 0.0210±0.0222 and repeatability coefficient of 0.061. The digital system provided a slightly lower repeatability with a bias between readings of −0.0040±0.0343, mean absolute difference of 0.0266±0.0219 and repeatability coefficient of 0.069. When the two methods were compared, the log-transformed bias between readings was 0.0169±0.06 with higher values obtained with s-VHS, the repeatability coefficient being 0.124, with almost all points within ±2SD of the mean difference. The mean absolute difference between the two measurements was 0.042±0.046. Conclusions: Compared with movies recorded on videotapes, the direct storage of series of single digitalized images in CD-rom for IMT evaluation associates with a lower agreement (-28%) between replicate scans. This implies the need of sample size larger of about 28% when this technology is used in IMT-progression clinical trials. Funding: European Project, IMPROVE QLG1-CT-2002-00896.
Settore BIO/14 - Farmacologia
2009
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/140706
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