Cobalamin-deficient (Cbl-D) central neuropathy in the rat is associated with a locally increased expression of neurotoxic tumour necrosis factor-α (TNF-α) and a locally decreased expression of neurotrophic epidermal growth factor (EGF). These recent findings suggest that cobalamin oppositely regulates the expression of TNF-α and EGF, and raise the possibility that these effects might be independent of its coenzyme function. Furthermore, adult Cbl-D patients have high levels of TNF-α and low levels of EGF in the serum and cerebrospinal fluid. Serum levels of TNF-α and EGF of cobalamin-treated patients normalize concomitantly with haematological disease remission. These observations suggest that cobalamin deficiency induces an imbalance in TNF-α and EGF levels in biological fluids that might have a role in the pathogenesis of the damage caused by pernicious anaemia.
New insights into the pathophysiology of cobalamin deficiency / G. Scalabrino, M. Peracchi. - In: TRENDS IN MOLECULAR MEDICINE. - ISSN 1471-4914. - 12:6(2006), pp. 247-254. [10.1016/j.molmed.2006.04.008]
New insights into the pathophysiology of cobalamin deficiency
G. ScalabrinoPrimo
;M. PeracchiUltimo
2006
Abstract
Cobalamin-deficient (Cbl-D) central neuropathy in the rat is associated with a locally increased expression of neurotoxic tumour necrosis factor-α (TNF-α) and a locally decreased expression of neurotrophic epidermal growth factor (EGF). These recent findings suggest that cobalamin oppositely regulates the expression of TNF-α and EGF, and raise the possibility that these effects might be independent of its coenzyme function. Furthermore, adult Cbl-D patients have high levels of TNF-α and low levels of EGF in the serum and cerebrospinal fluid. Serum levels of TNF-α and EGF of cobalamin-treated patients normalize concomitantly with haematological disease remission. These observations suggest that cobalamin deficiency induces an imbalance in TNF-α and EGF levels in biological fluids that might have a role in the pathogenesis of the damage caused by pernicious anaemia.Pubblicazioni consigliate
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